STOMACH Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection
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چکیده
suggests that colesevelam may be beneficial for patients with diarrhoea who have undergone small bowel resection forCrohn’s disease. There are no other published data to support its role in bile salt induced diarrhoea. Colesevelam is reported to be 4–6 times as potent as traditional bile salt sequestrants, possibly due to its greaterbinding affinity for glycocholic acid. It is administered in tablet form, and in one study the rate of compliance with colesevelamwas 93%. The unique hydrogel polymericPostScript441
منابع مشابه
Host gastric Lewis expression determines the bacterial density of Helicobacter pylori in babA2 genopositive infection.
BACKGROUND AND AIMS We tested if host gastric Lewis antigens and the babA2 genotype of Helicobacter pylori correlated with clinicohistological outcome. METHODS We enrolled 188 dyspeptic patients (45 with duodenal ulcer, 45 with gastric ulcer, and 98 with chronic gastritis) with H pylori infection, proved by culture and gastric histology, reviewed by the updated Sydney system. Gastric expressi...
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Helicobacter pylori (H. pylori) infection has been reported in more than half of the world human population. It is associated with gastric inflammation and noticeable infiltration of the immune cells to the stomach mucosa by several cytokines secretion. IL-1&beta, IL-18 have been shown to contribute to H. pylori induced gastritis, but the details of inflammation and association of virulence fac...
متن کاملExpression of Helicobacter pylori virulence factors and associated expression profiles of inflammatory genes in the human gastric mucosa.
Helicobacter pylori virulence factors have been suggested to be important in determining the outcome of infection. The H. pylori adhesion protein BabA2 is thought to play a crucial role in bacterial colonization and in induction of severe gastric inflammation, particularly in combination with expression of CagA and VacA. However, the influence of these virulence factors on the pathogenesis of H...
متن کاملMetastability of Helicobacter pylori bab adhesin genes and dynamics in Lewis b antigen binding.
Heterogeneity among Helicobacter pylori strains in gastric epithelial adherence is postulated to contribute to pathogen fitness in the physiologically diverse human population. H. pylori adherence to ABO and Lewis b (Leb) blood group antigens in the human stomach is mediated by the blood group antigen-binding adhesin BabA. Approximately 70% of Swedish and U.S. H. pylori clinical isolates exhibi...
متن کاملCytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection.
BACKGROUND AND AIMS Recent studies linked cytokine gene polymorphisms to H pylori related gastric cancer development. The current study evaluated the role of cytokine gene polymorphisms for mucosal cytokine expression, the gastric inflammatory response, and bacterial colonisation during H pylori infection. PATIENTS AND METHODS In 207 H pylori infected patients with chronic gastritis, polymorp...
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